Clinical Studies on Ashwagandha

Ashwagandha (Withania somnifera) 

Ashwagandha is a traditional adaptogenic herb recognized for supporting the body’s natural ability to maintain balance during everyday challenges.*

Summary of Research on Ashwagandha 

Research has explored ashwagandha’s role in supporting normal physiological processes related to stress adaptation, mood balance, restful sleep, and overall vitality. Key areas of study include:

General Health-Promoting Properties

• Studies have investigated ashwagandha’s potential to support normal physiological resilience, including adaptogenic effects and contributions to everyday well-being.*

• Links: 

• Ashwagandha and stress | Journal of Education, Health and Sport (Sobota et al., 2024)

• Cukurova Medical Journal » Submission » Clinical applications of Ashwagandha plant in depression and anxiety (Güllü et al., 2024)

• Exploring the therapeutic potential of Ashwagandha (Withania somnifera) supplementation in alleviating stress and stress-related disorders | Quality in Sport (Kuśmierska et al., 2024)

• The Multifaceted Effects of Ashwagandha (Withania somnifera) Root Extract on Physical Performance, Cognitive Function, Mental Health, and Safety in Adults | Quality in Sport (Zakrzewska et al., 2024)

• Ashwagandha (Withania somnifera)—Current Research on the Health-Promoting Activities: A Narrative Review (Mikulska et al., 2023)

• Potential clinical usage of ashwagandha root extract: A review | Journal of Education, Health and Sport (Potocka et al., 2023)

Stress Adaptation and Resilience

• Clinical investigations have assessed ashwagandha’s effects on normal responses to everyday stressors, noting support for healthy adaptation and balance.*

• Examples include studies measuring subjective perceptions of stress and related markers in healthy adults.*

• Links:

• An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera) (Pratte et al., 2014)

• An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study (Lopresti et al., 2019)

• A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults (Chandrasekhar et al., 2012)

• A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study (Majeed et al., 2023)

• Efficacy of Withania somnifera supplementation on adult's cognition and mood (Remenapp et al., 2022)

• Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Gopukumar et al., 2021)

• The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial (Baker et al., 2022)

• Effects of Withania somnifera Extract in Chronically Stressed Adults: A Randomized Controlled Trial (Pandit et al., 2024)

• Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study (Salve et al., 2019)

• Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review (Grabowski et al., 2024)

• Ashwagandha as an Adaptogen: Its Influence on Sleep Patterns, Stress Response, and Anxiety in Modern Life (Haber et al., 2024)

• The impact of ashwagandha on sleep quality, anxiety reduction, and stress lowering: comparative analysis of available studies (Malec, 2024)

• Exploring the Therapeutic Potential of Ashwagandha (Withania somnifera) in Alleviating Stress and Anxiety (Prajapati et al., 2025)

• Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis (Arumugam et al., 2024)

• Effects of Four-Week Supplementation of Ashwagandha and B-Vitamins on Mood and Stress Relief (Ching Chai et al., 2020)

Mood and Emotional Well-Being

• Research has examined ashwagandha’s influence on normal mood pathways and emotional balance in healthy adults under typical daily conditions.*

  • Examples include controlled trials observing mood-related outcomes and psychological well-being.*

  • Links: 

  • Therapeutic Effect of Withania somnifera (Ashwagandha) on Depression: A comprehensive review (Ibrahim et al., 2024)

  • Efficacy of Withania somnifera supplementation on adult's cognition and mood (Remenapp et al., 2022)

  • Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Gopukumar et al., 2021)

  • A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults (Chandrasekhar et al., 2012)

Restful Sleep Patterns

• Investigations have evaluated ashwagandha’s support for normal sleep architecture, restful patterns, and sleep quality in healthy individuals or those with occasional sleep challenges.*

• Examples include trials assessing sleep parameters and overall restfulness.*

• Links:

• The impact of ashwagandha on sleep quality, anxiety reduction, and stress lowering: comparative analysis of available studies (Malec, 2024)

• • Ashwagandha as an Adaptogen: Its Influence on Sleep Patterns, Stress Response, and Anxiety in Modern Life (Haber et al., 2024)

  • Unlocking Better Sleep and Stress Relief: The Power of Ashwagandha (Withania somnifera) Supplementation – A Literature Review (Grabowski et al., 2024)

  • Ashwagandha (Withania somnifera) - influence on sleep: review (Jędruszczak et al., 2023)

• • The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial (Baker et al., 2022)

  • The Impact of Ashwagandha on Stress, Sleep Quality, and Food Cravings in College Students: Quantitative Analysis of a Double-Blind Randomized Control Trial (O’Connor et al., 2022)

• • Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Gopukumar et al., 2021)

  • Clinical evaluation of the pharmacological impact of ashwagandha root extract on sleep in healthy volunteers and insomnia patients: A double-blind, randomized, parallel-group, placebo-controlled study (Langade et al., 2021)

  • Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study (Kelgane et al., 2020)

• • Efficacy and Safety of Ashwagandha (Withania somnifera) Root Extract in Insomnia and Anxiety: A Double-blind, Randomized, Placebo-controlled Study (Langade et al., 2019)

  • Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study (Salve et al., 2019)

• • A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults (Deshpande et al., 2020)

Cortisol Balance & Healthy Stress Response 

• Research has explored ashwagandha’s role in supporting normal cortisol regulation and the body’s adaptive response to everyday stressors.*

• Multiple randomized, double-blind, placebo-controlled studies have investigated ashwagandha supplementation in healthy adults, noting support for normal cortisol levels and healthy adaptation to daily demands.*

• Ashwagandha was generally well-tolerated in these trials, with mild or no reported adverse events in most cases.*

• Links:

• Ashwagandha as an Adaptogen: Its Influence on Sleep Patterns, Stress Response, and Anxiety in Modern Life (Haber et al., 2024)

• Effects of Ashwagandha (Withania Somnifera) on stress and anxiety: A systematic review and meta-analysis (Arumugam et al., 2024)

• A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study (Majeed et al., 2023)

• Efficacy of Withania somnifera supplementation on adult's cognition and mood (Remenapp et al., 2022)

• Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Gopukumar et al., 2021)

• An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study (Lopresti et al., 2019)

• Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study (Salve et al., 2019)

• A prospective, randomized double-blind, placebo-controlled study of safety and efficacy of a high-concentration full-spectrum extract of ashwagandha root in reducing stress and anxiety in adults  (Chandrasekhar et al., 2012)

Cognitive Function and Mental Clarity

• Some studies have explored ashwagandha’s potential to support normal cognitive processes, attention, memory, and mental performance under everyday demands.*

• Examples include assessments of cognitive tasks and executive function in healthy adults.*

• Links:

• Acute and Repeated Ashwagandha Supplementation Improves Markers of Cognitive Function and Mood (Leonard et al., 2024)

• • Safety and Efficacy of Ashwagandha Root Extract on Cognition, Energy and Mood Problems in Adults: Prospective, Randomized, Placebo-Controlled Study (Kale et al., 2024)

  • A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study (Majeed et al., 2023)

  • Efficacy of Withania somnifera supplementation on adult's cognition and mood (Remenapp et al., 2022)

  • The Perceived Impact of Ashwagandha on Stress, Sleep Quality, Energy, and Mental Clarity for College Students: Qualitative Analysis of a Double-Blind Randomized Control Trial (Baker et al., 2022)

  • Effects of Acute Ashwagandha Ingestion on Cognitive Function (Xing et al., 2022)

  • A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction (Ng et al., 2020)

  • Efficacy and Safety of Ashwagandha Root Extract on Cognitive Functions in Healthy, Stressed Adults: A Randomized, Double-Blind, Placebo-Controlled Study (Gopukumar et al., 2021)

  • Efficacy and Tolerability of Ashwagandha Root Extract in the Elderly for Improvement of General Well-being and Sleep: A Prospective, Randomized, Double-blind, Placebo-controlled Study (Kelgane et al., 2020)

  • Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions (Choudhary et al., 2017)

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. The summaries above reference general research on ashwagandha and do not represent specific claims about NeuroVital Serenity. Consult a healthcare professional before use, and see full studies for details.